Please remember that you will have started your journey quite some time before you arrive in France, and that the hour goes forward between the UK and France, so don't drive too far, feeling that you should get as many kilometres under your belt (so to speak) before stopping for the night.... after all there are lovely places to visit en route before you actually arrive at your eventual destination.
To help you plan your route, why not visit
http://www.viamichelin.fr , which will give you some idea of times and distances. If you are looking for low budget but clean chain accommodation, you could look up Formule1 (NON-en suite rooms) or Etap hotels (with shower and wc in room) - both part of the Accor chain. Other chains such as Campanile, Ibis, (2*s), Mercure (3*s) and Novotel (4*s) are also close to major roads, and provide standardised rooms at reasonable prices for what they offer.
I am sure that many readers will be able to supplement my post with individual recommendations, but please take it slow and steady ... driving on the wrong side of the road, unknown towns and road signs, dodgy weather and traffic jams all contribute to a weary feeling you would perhaps not feel doing a similar distance at home.
Apart from that, enjoy your holiday ..... including the getting there and getting home.