The RE4 and RE5 (regional trains) run daily from Shönefeld Airport to Alexanderplatz. They run every 30 minutes between approx 4:30am and 11pm.
You can also take the S-Bahn (S9) to and from Schönefeld, but that takes a wee bit longer.
Station is to your left outside airport along a covered walkway.
Have stayed in Agon hotel in Berlin before but not the Alexanderplatz. Would not hesitate using that chain again.
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