Yes its simple to do it ! You can visit most of the nearby Cycladic islands for a day - or if you like it - stay over & make a trip of it ! Check the flying dolphins website (if they have one ) as these are faster boats than the inter-island ferries . You'll find they all run most days there & back & you can buy the tickets at travel agencies or at the port - Athinios (it's miles to get down there on a zig-zag road with some hair raising twists & turns , so you will need to get a bus or taxi )
They are not expensive and you will need to be at the port about 1/2 hr before it's due to go.
We went to Naxos (about 5 hr trip ) once & then another time to Ios , takes about 4hrs.