I haven't used them but have seen several Times travel section articles that mention Cruise America as the company they used and gave good reviews. Have a look at http://www.Koa.com- these are a chain of campgrounds all over the US- you can link to CruiseAmerica via their site and get a 10% discount.
Should give you a place to start......

My advice would be to hire a car and stay in hotels. There won't be a lot of difference in the price, once you have taken into account mileage charges and site fees. Plus there are often restrictions on the use of a motorhome, which can be inconvenient.

I'm with JohnP on this one. Many people hire motorhomes and enjoy this kind of holiday the world over. We did it in New Zealand and had a whale of a time, however NZ is geared up for this type of travel. I'm sure people will argue Western USA is as well but with the ridiculous motel prices on offer in the States, and the excellent exchange rate, it will probably work out cheaper to do as JohnP says and just hire a car and stay in these places.

In the past we have taken advantage of rates as low as $20 just off the interstates. Of course if you go up a bit to $40+ you can get the likes of Motel 6, Super 8, Red Roof Inns and even some Travelodges and Quality Inns. On International Drive in Orlando we paid just $39 for the Quality Inn Plaza in October 2006, and the same price for the Comfort Inn LBV.

For an idea on car hire including all charges I always use http://www.dollar.co.uk for reference. Most of the time they offer the best rate anyway with the added security of knowing everything is included and there are no hidden fees. They will also quote you one way drop off fees if you decide to fly in and out of different airports.

Good luck

One of the the benefits of having a holiday with a Motorhome is only having to unpack once,also if you are miles from anywhere and you want something to eat, well you have got your kitchen with you and are able to make a hot drink when you want or get a cold one out of the fridge. Have done motorholme holidays over the last 30 years in the USA, Canada and New Zealand. In both New Zealand and Canada we had a few days when it poured with rain and twice we got absolutely drenched, if we had been in a car we would have had to get in to the car wet through and drive to a hotel, in the motorhome we could just change clothes and make a hot drink and relax in comfortable surroundings until we felt like moving on.
Although I often have holidays where I hire a car and stay in hotels for anything longer than a few days of touring and living out of a suitcase I prefer Motorhome holidays and hope to take many more.
I'm pretty sure I have seen packages that include flights and camper hire I think it was Virgin Holidays.

Hi Ajay,
Judith is right, Virgin Holidays do motor home holidays - http://www.virginholidays.co.uk/brochures/usa/info/flydrive/motorhomes/
You could also try these websites - usa.motorhome-holidays.com and http://www.funwayholidays.co.uk/tours/motorhomes.asp

Thanks for the replies.
We have to agree with Judith and puddleduck2. We really do want to try a motorhome and agree with the convenience it would offer us.
We have been looking at motor-home-hire dot com and had a quote of $1295 for 10 days (not including $166 for a convenience pack).
We will take a look at the links you have given and post back with a caomparison.
Thanks again.

Any further advice would be apprecieted -
Cheers
Andy

Andy
Just read your origional post where you said you would like to hire a 4/5 berth. Our last holiday in a Camper was in a 2 berth and it was far too small, after about a week we were really finding the space cramped. Previously we had hired 4berth ones and found them just right,with lots of room to stretch out. If we have a camper holiday again we will definitely hire the larger model.