I would have to disagree with Karen on the better location out of the Quality Inn International and Quality Inn Plaza.
The QIP is located in the far nicer part of I Drive, south of Sand Lake, and this part of I Drive is tree lined with pavements and flowers and lovely thick grass. You feel like you are in a totally different world compared to the built up and more commercial north part of I Drive. Whilst there is a greater concentration of restaurants (and hotels) north of Sand Lake, there are still plenty of options food wise within walking distance from the QIP (Tony Roma's being one such restaurant). You will also find Pirates Cove Mini Golf near the QIP and places like Wonderworks and the Pointe Orlando and Mercado, although I must say the Pointe and Mercado have seen better days.
As for ease of access to I4, well I would say that the QIP is easier. Turn right out of the hotel, past the convention centre and Rosen Center and then at the traffic lights at the bottom, follow the signs to I4 and go around the loop and there you are. An even quicker way to the Downtown Disney entrance to WDW is via Sand Lake Road, Dr Phillips Blvd and Apopka Vineland, which is the way I would head to Disney from either the QIP or QII to be honest.
For Universal if you stay south of Sand Lake you have the option of taking Universal Blvd and therefore avoiding the build up of traffic that seems to be always present north of Sand Lake. Seaworld is 5mins drive, even walkable from the QIP although across some busy roads but it is doable.
If I had to choose between the QIP or QII the Plaza would win everyday. Better and quieter location, great rooms (and newly renovated in some blocks) and with some great restaurants and attractions within walking distance. The QII would be a good 2nd choice though and I am pleased that Karen is enjoying it there. The only time we tried to book the QII it was full, so ended up at the Rodeway further north.
HTH