Oap, not sure when you are going - did you say?
You will find that people do have different opinions on what is the best area. I tend to enjoy slightly further north than most (I would even stay at Wynn!). Not futher north than Wynn though...
We spend most time in the Harrah's area approximately, although IP and Harrah's rooms could be noisy due to Carnaval Court. I've heard Flamingo is perfectly acceptable as a hotel. I'm sort of itching to try The Mirage. Never seem to find a good rate! I think we'll probably split between Orleans (where we'll have a car) and then somewhere on the strip. Venetian, Mirage, TI, or similar. Maybe even Planet Hollywood - it was one of our old favourites as Aladdin. I'm tempted by MGM's offers, and I was also impressed when I looked up Signature. I'm quite fond of Caesars but I think their rates are OTT for their basic rooms considering those rooms don't look that great.
I'm sort of tempted by the idea of a nice pool, lazy river etc just to see what a 'great vegas pool' is like.