Hi Dee, I would be very sceptical about that review. I have looked at it myself and suspect that the comment about the safe problems is because the person who posted it was disgruntled about the hotel but god knows why when all the other reviews are so so positive.
Having stayed at this hotel on 3 occasions I find it difficult to believe that this could happen because all the safes are the modern type where you have a unique number that you set yourself.
My friend returned from this hotel on 12th June after a 14 night stay and I'm sure that if anything like this had happened whilst she was staying there then she would have been the first to here about it cos she's dead nosey
I wouldn't worry about it too much. Prior to our holiday at the Pelicanos there were a couple of reviews similar to that although not on the same scale as the one that you have just mentioned but we didn't experience or hear of anything like that happening during our visit even though I left the safe open one day for about 8 hours.
Sue